About Course
Metabolic engineering is an emerging field of biotechnology/bioprocess engineering which aims towards the purposeful modification of cellular (metabolic, gene regulatory, and signaling) processes/networks to achieve desirable goals such as enhanced production of metabolites including pharmaceuticals, biofuels and biochemicals, and other biotechnology products.
This course aims to provide fundamental and advanced knowledge in the development of microbial strain for bioproduction through metabolic engineers.
Course Content
Metabolic Engineering
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01 Virtual Welcome
03:01 -
02 Group Projects
08:51 -
03 Intro to MFA
00:00 -
04 Metabolic Databases
00:00 -
05 Intro to FBA
00:00 -
06 FBA Part 2
00:00 -
07 FBA Part 3
00:00 -
08 GEM Database
00:00 -
09 GEM Files
00:00 -
10 OptKnock
00:00 -
11 Intro to 13C MFA
00:00 -
12 13C MFA Part 2
00:00 -
13 13C MFA Part 3
00:00 -
14 Regulatory Modalities
00:00 -
15 Positive & Negative
00:00 -
16 Negative Feedback
00:00 -
17 Trp Operon
00:00 -
18 Feedback Resistant Enzymes
00:00 -
19 RNA Polymerase Anatomy
00:00 -
20 Promoters
00:00 -
21 The Ribosome Binding Site
00:00 -
22 The RBS Calculator
00:00 -
23 Tradeoffs of translation
00:00 -
24 Inducible promoters
00:00 -
25 Building biosensors
00:00 -
26 Biosensor details
00:00 -
27 TF Cooperativity
00:00 -
28 Dynamic knockdown
00:00 -
29 Industrial DMC
00:00 -
30 Synthetic circuits
00:00 -
31 Genome editing
00:00 -
32 Nucleases
00:00 -
33 CRISPR Metabolic Engr
00:00 -
34 Recombineering
00:00 -
35 MAGE
00:00 -
36 MAGE Applied
00:00 -
37 Genomes for new chemistry
00:00 -
38 Genomes & aldehydes
00:00 -
39 Aldehyde reductases
00:00 -
40 Creating a RARE genome
00:00 -
41 Recoded E. coli
00:00 -
42 Other recoded genomes
00:00 -
43 Expanded genetic alphabet
00:00 -
44 Minimal genomes
00:00 -
45 Refactored genomes
00:00 -
46 De novo pathways
00:00 -
47 Experimental design steps
00:00 -
48 Retrobiosynthesis
00:00 -
49 Unnatural targets
00:00
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