Medicinal Chemistry

About Course

Medicinal Chemistry.

The main objective of this course is to familiarize students with the fundamental concepts of drug discovery and development. The course is intended for students who have a background in chemistry and interested in the process of drug discovery. The intended outcome is to train students on various aspects of new drug discovery/development, drug screening, target identification, lead discovery, optimization, and the molecular basis of drug design and drug action.

INTENDED AUDIENCE: Third-year undergraduates of B.Sc. Chemistry; M.Sc. Chemistry students and doctoral students

Week 1: An overview of drugs and drug targets
Week 2: Principles of enzyme structure, catalysis, and inhibition in drug discovery
Week 3: Receptors function and ligand binding interactions
Week 4: Nucleic acids structure and function
Week 5: Synthetic methods in medicinal chemistry
Week 6: Lead discovery; Bioassays; drug targets
Week 7: Lead discovery
Week 8: Drug metabolism and pharmacology
Week 9: Prodrugs and drug delivery systems
Week 10: Drug resistance mechanisms and synergism
Week 11: Drug resistance mechanisms and synergism

Course Content

Medicinal Chemistry

Introduction to Medicinal Chemistry Part-I

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Introduction to Medicinal Chemistry Part-II

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Tutorial 01-Acidity, Basicity and Related concepts

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Tutorial 02-Basic Concepts of Thermodynamics and Kinetics

00:00
Tutorial 03- Binding Forces, Protein Structure and Function

00:00
Tutorial 04- Receptors, Binding Interactions, Ion Channels

00:00
Tutorial 05-Nucleic acids, and Basics of Molecular Biology

00:00
Tutorial 06-Enzyme Kinetics, Various Modes of Inhibition etc.

00:00
Tutorial 07-Receptor-Drug Interactions, Stereochemistry, Chirality, Nomenclature

00:00
Tutorial 08-Determination of Drug-Receptor Interactions, Conformation of Cyclic and Acyclic Structur

00:00
Tutorial 09-Nucleic Acids and Related Topics

00:00
Tutorial 10-ADME

00:00
Tutorial 11-Drug administration routes and finding a lead

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Tutorial 12

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Tutorial 13- Optimizing Access-Prodrugs

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Intermolecular Binding Forces

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Protein Structure and Function

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Enzyme Catalysis Part-I

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Enzyme Catalysis Part-II

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Introduction to Receptors

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Receptor Types and Functions

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Enzymes as Drug Targets

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Enzyme Kinetics and Inhibition

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Receptors as Drug Targets Part-I

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Receptors as Drug Targets Part-II

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Pharmacokinetics Part-I

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Pharmacokinetics Part-II

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Finding a Lead Part-I

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Finding a Lead Part-II

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Optimizing Drug-Target Interactions Part-I

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Optimizing Drug-Target Interactions Part-II

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Optimizing Drug-Target Interactions Part-III

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Optimizing Drug-Target Interactions Part-IV

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Endogenous Compounds, Peptidomimetics and Oligonucleotides as Drugs

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Nucleic Acids

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RNA and Protein Synthesis

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Receptor-Drug Interactions.

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Nucleic Acids as Drug Targets Part-I

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Nucleic Acids as Drug Targets Part-II

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Miscellaneous Drug Targets

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Mechanisms in Biological Chemistry Part-I

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Mechanisms in Biological Chemistry Part-II

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Mechanisms in Biological Chemistry Part-III

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Drug Metabolism Part-I

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Drug Metabolism Part-II

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Drug Metabolism Part-III

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Drug Metabolism Part-IV

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Drug Administration Routes Part-I

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Drug Administration Routes Part-II

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Drug Screening

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Optimizing Access to the Target

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Stereochemistry and Conformation

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Prodrugs

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Prodrugs and Drug Alliances

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About Course

Medicinal Chemistry.

What Will You Learn?

Course Content

Medicinal Chemistry

Introduction to Medicinal Chemistry Part-I

Introduction to Medicinal Chemistry Part-II

Tutorial 01-Acidity, Basicity and Related concepts

Tutorial 02-Basic Concepts of Thermodynamics and Kinetics

Tutorial 03- Binding Forces, Protein Structure and Function

Tutorial 04- Receptors, Binding Interactions, Ion Channels

Tutorial 05-Nucleic acids, and Basics of Molecular Biology

Tutorial 06-Enzyme Kinetics, Various Modes of Inhibition etc.

Tutorial 07-Receptor-Drug Interactions, Stereochemistry, Chirality, Nomenclature

Tutorial 08-Determination of Drug-Receptor Interactions, Conformation of Cyclic and Acyclic Structur

Tutorial 09-Nucleic Acids and Related Topics

Tutorial 10-ADME

Tutorial 11-Drug administration routes and finding a lead

Tutorial 12

Tutorial 13- Optimizing Access-Prodrugs

Intermolecular Binding Forces

Protein Structure and Function

Enzyme Catalysis Part-I

Enzyme Catalysis Part-II

Introduction to Receptors

Receptor Types and Functions

Enzymes as Drug Targets

Enzyme Kinetics and Inhibition

Receptors as Drug Targets Part-I

Receptors as Drug Targets Part-II

Pharmacokinetics Part-I

Pharmacokinetics Part-II

Finding a Lead Part-I

Finding a Lead Part-II

Optimizing Drug-Target Interactions Part-I

Optimizing Drug-Target Interactions Part-II

Optimizing Drug-Target Interactions Part-III

Optimizing Drug-Target Interactions Part-IV

Endogenous Compounds, Peptidomimetics and Oligonucleotides as Drugs

Nucleic Acids

RNA and Protein Synthesis

Receptor-Drug Interactions.

Nucleic Acids as Drug Targets Part-I

Nucleic Acids as Drug Targets Part-II

Miscellaneous Drug Targets

Mechanisms in Biological Chemistry Part-I

Mechanisms in Biological Chemistry Part-II

Mechanisms in Biological Chemistry Part-III

Drug Metabolism Part-I

Drug Metabolism Part-II

Drug Metabolism Part-III

Drug Metabolism Part-IV

Drug Administration Routes Part-I

Drug Administration Routes Part-II

Drug Screening

Optimizing Access to the Target

Stereochemistry and Conformation

Prodrugs

Prodrugs and Drug Alliances

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