Medicinal Chemistry

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About Course

Medicinal Chemistry.

The main objective of this course is to familiarize students with the fundamental concepts of drug discovery and development. The course is intended for students who have a background in chemistry and interested in the process of drug discovery. The intended outcome is to train students on various aspects of new drug discovery/development, drug screening, target identification, lead discovery, optimization, and the molecular basis of drug design and drug action.

INTENDED AUDIENCE: Third-year undergraduates of B.Sc. Chemistry; M.Sc. Chemistry students and doctoral students

What Will You Learn?

  • Week 1: An overview of drugs and drug targets
  • Week 2: Principles of enzyme structure, catalysis, and inhibition in drug discovery
  • Week 3: Receptors function and ligand binding interactions
  • Week 4: Nucleic acids structure and function
  • Week 5: Synthetic methods in medicinal chemistry
  • Week 6: Lead discovery; Bioassays; drug targets
  • Week 7: Lead discovery
  • Week 8: Drug metabolism and pharmacology
  • Week 9: Prodrugs and drug delivery systems
  • Week 10: Drug resistance mechanisms and synergism
  • Week 11: Drug resistance mechanisms and synergism

Course Content

Medicinal Chemistry

  • Introduction to Medicinal Chemistry Part-I
    00:00
  • Introduction to Medicinal Chemistry Part-II
    00:00
  • Tutorial 01-Acidity, Basicity and Related concepts
    00:00
  • Tutorial 02-Basic Concepts of Thermodynamics and Kinetics
    00:00
  • Tutorial 03- Binding Forces, Protein Structure and Function
    00:00
  • Tutorial 04- Receptors, Binding Interactions, Ion Channels
    00:00
  • Tutorial 05-Nucleic acids, and Basics of Molecular Biology
    00:00
  • Tutorial 06-Enzyme Kinetics, Various Modes of Inhibition etc.
    00:00
  • Tutorial 07-Receptor-Drug Interactions, Stereochemistry, Chirality, Nomenclature
    00:00
  • Tutorial 08-Determination of Drug-Receptor Interactions, Conformation of Cyclic and Acyclic Structur
    00:00
  • Tutorial 09-Nucleic Acids and Related Topics
    00:00
  • Tutorial 10-ADME
    00:00
  • Tutorial 11-Drug administration routes and finding a lead
    00:00
  • Tutorial 12
    00:00
  • Tutorial 13- Optimizing Access-Prodrugs
    00:00
  • Intermolecular Binding Forces
    00:00
  • Protein Structure and Function
    00:00
  • Enzyme Catalysis Part-I
    00:00
  • Enzyme Catalysis Part-II
    00:00
  • Introduction to Receptors
    00:00
  • Receptor Types and Functions
    00:00
  • Enzymes as Drug Targets
    00:00
  • Enzyme Kinetics and Inhibition
    00:00
  • Receptors as Drug Targets Part-I
    00:00
  • Receptors as Drug Targets Part-II
    00:00
  • Pharmacokinetics Part-I
    00:00
  • Pharmacokinetics Part-II
    00:00
  • Finding a Lead Part-I
    00:00
  • Finding a Lead Part-II
    00:00
  • Optimizing Drug-Target Interactions Part-I
    00:00
  • Optimizing Drug-Target Interactions Part-II
    00:00
  • Optimizing Drug-Target Interactions Part-III
    00:00
  • Optimizing Drug-Target Interactions Part-IV
    00:00
  • Endogenous Compounds, Peptidomimetics and Oligonucleotides as Drugs
    00:00
  • Nucleic Acids
    00:00
  • RNA and Protein Synthesis
    00:00
  • Receptor-Drug Interactions.
    00:00
  • Nucleic Acids as Drug Targets Part-I
    00:00
  • Nucleic Acids as Drug Targets Part-II
    00:00
  • Miscellaneous Drug Targets
    00:00
  • Mechanisms in Biological Chemistry Part-I
    00:00
  • Mechanisms in Biological Chemistry Part-II
    00:00
  • Mechanisms in Biological Chemistry Part-III
    00:00
  • Drug Metabolism Part-I
    00:00
  • Drug Metabolism Part-II
    00:00
  • Drug Metabolism Part-III
    00:00
  • Drug Metabolism Part-IV
    00:00
  • Drug Administration Routes Part-I
    00:00
  • Drug Administration Routes Part-II
    00:00
  • Drug Screening
    00:00
  • Optimizing Access to the Target
    00:00
  • Stereochemistry and Conformation
    00:00
  • Prodrugs
    00:00
  • Prodrugs and Drug Alliances
    00:00
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