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Medicinal Chemistry

  • Course level: Beginner
  • Categories C-Science
  • Last Update 24/06/2021

Description

Medicinal Chemistry.

The main objective of this course is to familiarize students with the fundamental concepts of drug discovery and development. The course is intended for students who have a background in chemistry and interested in the process of drug discovery. The intended outcome is to train students on various aspects of new drug discovery/development, drug screening, target identification, lead discovery, optimization, and the molecular basis of drug design and drug action.

INTENDED AUDIENCE: Third-year undergraduates of B.Sc. Chemistry; M.Sc. Chemistry students and doctoral students

What Will I Learn?

  • Week 1: An overview of drugs and drug targets
  • Week 2: Principles of enzyme structure, catalysis, and inhibition in drug discovery
  • Week 3: Receptors function and ligand binding interactions
  • Week 4: Nucleic acids structure and function
  • Week 5: Synthetic methods in medicinal chemistry
  • Week 6: Lead discovery; Bioassays; drug targets
  • Week 7: Lead discovery
  • Week 8: Drug metabolism and pharmacology
  • Week 9: Prodrugs and drug delivery systems
  • Week 10: Drug resistance mechanisms and synergism
  • Week 11: Drug resistance mechanisms and synergism

Topics for this course

69 Lessons

Medicinal Chemistry

Introduction to Medicinal Chemistry Part-I00:00:00
Introduction to Medicinal Chemistry Part-II00:00:00
Tutorial 01-Acidity, Basicity and Related concepts00:00:00
Tutorial 02-Basic Concepts of Thermodynamics and Kinetics00:00:00
Tutorial 03- Binding Forces, Protein Structure and Function00:00:00
Tutorial 04- Receptors, Binding Interactions, Ion Channels00:00:00
Tutorial 05-Nucleic acids, and Basics of Molecular Biology00:00:00
Tutorial 06-Enzyme Kinetics, Various Modes of Inhibition etc.00:00:00
Tutorial 07-Receptor-Drug Interactions, Stereochemistry, Chirality, Nomenclature00:00:00
Tutorial 08-Determination of Drug-Receptor Interactions, Conformation of Cyclic and Acyclic Structur00:00:00
Tutorial 09-Nucleic Acids and Related Topics00:00:00
Tutorial 10-ADME00:00:00
Tutorial 11-Drug administration routes and finding a lead00:00:00
Tutorial 1200:00:00
Tutorial 13- Optimizing Access-Prodrugs00:00:00
Intermolecular Binding Forces00:00:00
Protein Structure and Function00:00:00
Enzyme Catalysis Part-I00:00:00
Enzyme Catalysis Part-II00:00:00
Introduction to Receptors00:00:00
Receptor Types and Functions00:00:00
Enzymes as Drug Targets00:00:00
Enzyme Kinetics and Inhibition00:00:00
Receptors as Drug Targets Part-I00:00:00
Receptors as Drug Targets Part-II00:00:00
Pharmacokinetics Part-I00:00:00
Pharmacokinetics Part-II00:00:00
Finding a Lead Part-I00:00:00
Finding a Lead Part-II00:00:00
Optimizing Drug-Target Interactions Part-I00:00:00
Optimizing Drug-Target Interactions Part-II00:00:00
Optimizing Drug-Target Interactions Part-III00:00:00
Optimizing Drug-Target Interactions Part-IV00:00:00
Endogenous Compounds, Peptidomimetics and Oligonucleotides as Drugs00:00:00
Nucleic Acids00:00:00
RNA and Protein Synthesis00:00:00
Receptor-Drug Interactions.00:00:00
Nucleic Acids as Drug Targets Part-I00:00:00
Nucleic Acids as Drug Targets Part-II00:00:00
Miscellaneous Drug Targets00:00:00
Mechanisms in Biological Chemistry Part-I00:00:00
Mechanisms in Biological Chemistry Part-II00:00:00
Mechanisms in Biological Chemistry Part-III00:00:00
Drug Metabolism Part-I00:00:00
Drug Metabolism Part-II00:00:00
Drug Metabolism Part-III00:00:00
Drug Metabolism Part-IV00:00:00
Drug Administration Routes Part-I00:00:00
Drug Administration Routes Part-II00:00:00
Drug Screening00:00:00
Optimizing Access to the Target00:00:00
Stereochemistry and Conformation00:00:00
Prodrugs00:00:00
Prodrugs and Drug Alliances00:00:00
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Medicinal Chemistry
Free

Enrolment validity: Lifetime

Requirements

  • Any student who has done basic organic chemistry and has some knowledge of biochemistry with an interest in drug discovery