Essentials of Biomolecules: Nucleic Acids and Peptides

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About Course

Essentials of Biomolecules: Nucleic Acids and Peptides.

The proposed course aims to provide the essentials of chemistry and biology of two very important classes of biomolecules: nucleic acids (DNA/RNA) and proteins.

The course allows us to decipher: how structural features are translated into biological functions; how highly organized and selective chemical reactions are adopted that allows DNA to replicate or dictates step-wise synthesis of a specific sequence of proteins; how organic chemistry tools in combination with enzymes were ingeniously applied to determine sequences of DNA and proteins and how chemical modifications could be done to mimic similar biological properties.

The course also includes modern techniques, the development of biomolecular probes as high-throughput detection of biomolecules, single nucleotide polymorphisms, and disease diagnosis. Overall, the course falls within the domain of organic chemistry and chemical biology.

INTENDED AUDIENCE: For chemistry, Biochemistry, and Biotechnology students

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What Will You Learn?

  • Week 1: Introduction, Nucleic acids, and proteins
  • Week 2: Synthesis of nucleobases, nucleotides, and oligonucleotides
  • Week 3: Solid-phase synthesis of oligonucleotides
  • Week 4: DNA replication, Polymerases, DNA sequencing, and PCR
  • Week 5: DNA damage, mutations, and cancer
  • Week 6: DNA to proteins: transcription, translation and genetic code
  • Week 7: Peptides, sequencing, and applications in therapeutics
  • Week 8: Solution phase and solid-phase peptide synthesis
  • Week 9: Expansion of genetic code: PNA, LNA, and molecular probes
  • Week 10: Modern techniques for biomolecules and disease diagnosis
  • Week 11: Structures and chemistry of sugars and carbohydrates
  • Week 12: Carbohydrate based polymers as biomolecular probes and therapeutics; conclusion

Course Content

Essentials of Biomolecules: Nucleic Acids and Peptides

  • Lec 1: Importance of Biomolecules
    00:00
  • Lec 2: DNA double helix: Chemical parameters
    00:00
  • Lec 3: DNA and Proteins
    00:00
  • Lec 4: Amino acids and Proteins
    00:00
  • Lec 5: Protein 3D structures, folding and denaturation
    00:00
  • Lec 6: Chemical synthesis pyrimidine nucleobases
    00:00
  • Lec 7: Chemical synthesis purine nucleobases, Prebiotic chemistry
    00:00
  • Lec 8: Synthesis of nucleosides
    00:00
  • Lec 9: Solid phase DNA synthesis
    00:00
  • Lec 10: Chemistry and Biology of DNA Replication
    00:00
  • Lec 11: Chemistry of Polymerase Chain Reaction
    00:00
  • Lec 12: Major components and steps involved in Polymerase chain reaction
    00:00
  • Lec 13: DNA sequencing: Sanger’s di-deoxy method
    00:00
  • Lec 14: DNA sequencing: Maxam- Gilbert method
    00:00
  • Lec 15: Numerical Problem – 1
    00:00
  • Lec 16: Sugar Chemistry
    00:00
  • Lec 17: Chemistry behind DNA damage and mutation
    00:00
  • Lec 18: Chemistry behind DNA damage and mutation
    00:00
  • Lec 19: DNA repair
    00:00
  • Lec 20: Transcription – The transfer of genetic information from DNA to mRNA
    00:00
  • Lec 21: Translation – The transfer of genetic information from mRNA to protein I
    00:00
  • Lec 22: Translation – The transfer of genetic information from mRNA to protein II
    00:00
  • Lec 23: Role of Ribosome in protein synthesis and the concept of codon
    00:00
  • Lec 24: Protein sequencing using Sanger’s and Edman’s degradation methods
    00:00
  • Lec 25: Mass spectroscopy and other sequencing methods for large proteins
    00:00
  • Lecture 26: Solution phase peptide synthesis : mechanism and end protection
    00:00
  • Lecture 27: Peptide coupling agents, Solid phase synthesis, peptide based therapeutics
    00:00
  • Lecture 28: Spectroscopic techniques
    00:00
  • Lecture 29: Spectrospic techniques -II and Purification technique-I of biomolecules
    00:00
  • Lecture 30: Purification techniques-II and Characterization techniques of biomolecules
    00:00
  • Lecture 31: Molecular probes : PNA and LNA-I
    00:00
  • Lecture 32: Molecular Probes: PNA and LNA – II
    00:00
  • Lecture 33: Carbohydrate chemistry-I: Introduction and Synthesis
    00:00
  • Lecture 34: Carbohydrate chemistry -II: Polysaccharides and its nanoparticles
    00:00
  • Lecture 35: Carbohydrate chemistry -III: Synthesis of nanoparticles; Recap of all modules.
    00:00

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